On Parameter Synthesis by Parallel Model Checking

J. Barnat, L. Brim, A. Krejčí, A. Streck, D. Šafránek, M. Vejnar, T. Vejpustek

IEEE/ACM Trans. Comput. Biology Bioinform. 9(3): 693-705 (2012)

An important problem in current computational systems biology is to analyze models of biological systems dynamics under parameter uncertainty. This paper presents a novel algorithm for parameter synthesis based on parallel model checking. The algorithm is conceptually universal with respect to the modeling approach employed. We introduce the algorithm, show its scalability, and examine its applicability on several biological models.